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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK2
All Species:
40.3
Human Site:
T525
Identified Species:
63.33
UniProt:
Q92630
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92630
NP_003574.1
601
66652
T525
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
Chimpanzee
Pan troglodytes
XP_509205
601
66595
T525
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
Rhesus Macaque
Macaca mulatta
XP_001117134
601
66643
T525
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
Dog
Lupus familis
XP_538273
601
66656
T525
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
Cat
Felis silvestris
Mouse
Mus musculus
Q5U4C9
599
66538
T523
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
Rat
Rattus norvegicus
Q4V8A3
586
65492
T511
W
D
P
S
A
R
L
T
P
A
Q
A
L
R
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511087
546
60615
S471
W
D
P
A
L
R
L
S
P
G
Q
A
L
R
H
Chicken
Gallus gallus
Q5ZIU3
526
59419
L455
R
M
T
P
S
Q
A
L
R
H
P
W
L
R
R
Frog
Xenopus laevis
NP_001088793
567
63329
T492
W
D
P
V
A
R
M
T
P
S
Q
A
M
R
H
Zebra Danio
Brachydanio rerio
NP_001038298
587
65453
T512
W
D
P
S
Q
R
M
T
P
S
Q
A
L
R
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P83102
828
92722
T579
W
D
A
D
K
R
L
T
P
S
E
A
L
K
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_001023208
796
87422
G724
A
G
A
R
S
K
R
G
K
M
R
G
P
P
A
Sea Urchin
Strong. purpuratus
XP_799140
561
63192
F482
D
D
P
L
F
L
D
F
L
K
R
C
L
E
W
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51566
467
54180
W396
R
D
S
L
K
A
V
W
K
L
P
R
L
P
N
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
T694
L
N
P
L
E
R
W
T
P
Q
Q
A
M
L
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
99.6
98.3
N.A.
97
59.7
N.A.
78.6
81.3
64.5
83.6
N.A.
43.3
N.A.
45.7
63.7
Protein Similarity:
100
98.8
99.8
99
N.A.
98.5
71.8
N.A.
83
84.5
75
89.8
N.A.
54.9
N.A.
55.6
73.5
P-Site Identity:
100
100
100
100
N.A.
100
73.3
N.A.
80
13.3
73.3
80
N.A.
53.3
N.A.
0
20
P-Site Similarity:
100
100
100
100
N.A.
100
86.6
N.A.
100
20
80
86.6
N.A.
73.3
N.A.
13.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.3
27.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
36.6
41.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
14
40
14
7
7
0
0
7
0
74
0
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% C
% Asp:
7
80
0
7
0
0
7
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
7
0
0
0
0
0
7
0
0
7
0
% E
% Phe:
0
0
0
0
7
0
0
7
0
0
0
0
0
0
0
% F
% Gly:
0
7
0
0
0
0
0
7
0
40
0
7
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
74
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
14
7
0
0
14
7
0
0
0
7
0
% K
% Leu:
7
0
0
20
7
7
20
7
7
7
0
0
80
7
0
% L
% Met:
0
7
0
0
0
0
47
0
0
7
0
0
14
0
0
% M
% Asn:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
7
% N
% Pro:
0
0
74
7
0
0
0
0
74
0
14
0
7
14
0
% P
% Gln:
0
0
0
0
7
7
0
0
0
7
67
0
0
0
0
% Q
% Arg:
14
0
0
7
0
74
7
0
7
0
14
7
0
67
7
% R
% Ser:
0
0
7
14
14
0
0
7
0
20
0
0
0
0
0
% S
% Thr:
0
0
7
0
0
0
0
67
0
0
0
0
0
0
0
% T
% Val:
0
0
0
7
34
0
7
0
0
0
0
0
0
0
0
% V
% Trp:
67
0
0
0
0
0
7
7
0
0
0
7
0
0
7
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _